Can you find any related output in the system.log (/Applications/Utilities/Console.app)?

from /Library/Logs/DiagnosticReports/Cyberduck_2015-03-01-114819_macbook-pro.hang

Here are the relevant lines from the system.log. Also the last line indicates that a hang report was saved in my computer. I have attached that to this ticket, too:

1/03/2015 11:46:10.074 AM com.github.norio-nomura.SIMBL-Agent[371]: warning: failed to get scripting definition from /Applications/ Internet/FTP/Cyberduck.app; it may not be scriptable.
1/03/2015 11:46:14.332 AM Cyberduck[505]: Error loading /Library/ScriptingAdditions/Adobe Unit Types.osax/Contents/MacOS/Adobe Unit Types: dlopen(/Library/ScriptingAdditions/Adobe Unit Types.osax/Contents/MacOS/Adobe Unit Types, 262): no suitable image found.  Did find:
	/Library/ScriptingAdditions/Adobe Unit Types.osax/Contents/MacOS/Adobe Unit Types: no matching architecture in universal wrapper
1/03/2015 11:46:15.054 AM Cyberduck[505]: Error loading /Users/mdwilliams/Library/ScriptingAdditions/24U Appearance OSAX.osax/Contents/MacOS/24U Appearance OSAX:  dlopen(/Users/mdwilliams/Library/ScriptingAdditions/24U Appearance OSAX.osax/Contents/MacOS/24U Appearance OSAX, 262): no suitable image found.  Did find:
	/Users/mdwilliams/Library/ScriptingAdditions/24U Appearance OSAX.osax/Contents/MacOS/24U Appearance OSAX: mach-o, but wrong architecture
1/03/2015 11:47:19.611 AM com.apple.xpc.launchd[1]: (ch.sudo.cyberduck.50584[505]) Service exited due to signal: Terminated: 15
1/03/2015 11:47:35.146 AM com.github.norio-nomura.SIMBL-Agent[371]: warning: failed to get scripting definition from /Applications/ Internet/FTP/Cyberduck.app; it may not be scriptable.
1/03/2015 11:47:38.619 AM Cyberduck[522]: Error loading /Library/ScriptingAdditions/Adobe Unit Types.osax/Contents/MacOS/Adobe Unit Types: dlopen(/Library/ScriptingAdditions/Adobe Unit Types.osax/Contents/MacOS/Adobe Unit Types, 262): no suitable image found.  Did find:
	/Library/ScriptingAdditions/Adobe Unit Types.osax/Contents/MacOS/Adobe Unit Types: no matching architecture in universal wrapper
1/03/2015 11:47:38.685 AM Cyberduck[522]: Error loading /Users/mdwilliams/Library/ScriptingAdditions/24U Appearance OSAX.osax/Contents/MacOS/24U Appearance OSAX:  dlopen(/Users/mdwilliams/Library/ScriptingAdditions/24U Appearance OSAX.osax/Contents/MacOS/24U Appearance OSAX, 262): no suitable image found.  Did find:
	/Users/mdwilliams/Library/ScriptingAdditions/24U Appearance OSAX.osax/Contents/MacOS/24U Appearance OSAX: mach-o, but wrong architecture
1/03/2015 11:48:19.885 AM spindump[513]: Saved hang report for Cyberduck version 4.6.5 (17000) to /Library/Logs/DiagnosticReports/Cyberduck_2015-03-01-114819_macbook-pro.hang

Hope this helps!

Mike

Can you uninstall com.github.norio-nomura.SIMBL-Agent and ~/Library/ScriptingAdditions/24U Appearance OSAX.osax to make sure we have no interoperability issue here.

Second diagnostic report

I removed the files you mentioned and rebooted. Still the same problem, though. I've attached the new DiagnosticReport, and here is the latest system.log report:

2/03/2015 1:57:58.755 PM CoreServicesUIAgent[414]: unexpected message <OS_xpc_error: <error: 0x7fff7d99ac60> { count = 1, contents =

"XPCErrorDescription" => <string: 0x7fff7d99af70> { length = 18, contents = "Connection invalid" }

}> 2/03/2015 1:57:58.835 PM com.apple.xpc.launchd[1]: (ch.sudo.cyberduck.50584[455]) Service exited due to signal: Terminated: 15 2/03/2015 1:58:22.722 PM Console[467]: Failed to connect (_consoleX) outlet from (NSApplication) to (ConsoleX): missing setter or instance variable 2/03/2015 1:58:22.823 PM Console[467]: Error loading /Users/mdwilliams/Library/ColorPickers/paintersPicker.colorPicker/Contents/MacOS/paintersPicker: dlopen(/Users/mdwilliams/Library/ColorPickers/paintersPicker.colorPicker/Contents/MacOS/paintersPicker, 265): no suitable image found. Did find:

/Users/mdwilliams/Library/ColorPickers/paintersPicker.colorPicker/Contents/MacOS/paintersPicker: no matching architecture in universal wrapper

2/03/2015 1:58:25.149 PM spindump[452]: Saved hang report for Cyberduck version 4.6.5 (17000) to /Library/Logs/DiagnosticReports/Cyberduck_2015-03-02-135825_macbook-pro.hang

I notice that this time it says something about a "colorPicker". That's odd, because I was not using any other application at the time, except Cyberduck which I launched immediately after a reboot.

Good luck!

I cannot reproduce this issue. Can you try if you also have this issue when using the Guest account on your computer.